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Difficulties in the selection of top-level terms for organ systems #967

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hansenp opened this issue Dec 18, 2024 · 0 comments
Open

Difficulties in the selection of top-level terms for organ systems #967

hansenp opened this issue Dec 18, 2024 · 0 comments

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@hansenp
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hansenp commented Dec 18, 2024

For a bioinformatic analysis, I need to define UPheno top-level terms for organ systems that have an equivalent in HPO. In HPO, such terms are at the top of the hierarchy under the term HP:0000118: Phenotypic abnormality. In UPheno, the corresponding terms are further down in the hierarchy, below very technical terms such as multicellular anatomical structure phenotype or material anatomical entity phenotype. In addition, the top-level terms in UPheno are not all in the same place, as is the case in HPO.

Due to the complex structure of UPheno I am unsure whether:

  1. I have selected the correct UPheno counterparts for the top-level terms from HPO.
  2. The UPheno top-level terms that I have chosen really include all terms that have to do with the respective organ system.

It might be useful to create some kind of convenience class in UPheno that contains top-level terms and is higher up in the hierarchy so that users are not confused by all the technical terms. But most importantly, all terms associated with a particular organ system must be below the corresponding top-level term in the hierarchy. See also #966.

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