ImPART Target Trial

IMproving Prophylactic Antibiotic use for Recurrent urinary Tract infection (IMPART) - target trial emulation

📝 Project Description

A retrospective cohort study designed using the Comparative Effectiveness Research Based on Observational Data to Emulate a Target Trial (CERBOT) tool, to emulate a pragmatic clinical trial assessing the effect of prophylactic antibiotic initiation versus usual care on subsequent antibiotic resistance.

The objective of this research is to estimate the effect of prophylactic antibiotic use on antibiotic resistance in women with recurrent urinary tract infections (rUTIs).

Authors

Dr Leigh Sanyaolu¹ General Practitioner and Health and Care Research Wales, NIHR Doctoral Fellow,
Dr Haroon Ahmed¹ General Practitioner and Clinical Reader in Epidemiology,
Ms Victoria Best² - Research Officer and Data Scientist,
Professor Daniel Farewell³ Professor of statistics,
Dr Simon Schoenbuchner³ – Statistician,
Professor Fiona Wood¹ – Professor of Medical Sociology,
Professor Adrian Edwards¹ - General Practitioner and Professor of General Practice,
Professor Ashley Akbari² – Professor of Population Data Science Research,
Associate Professor Gail Hayward⁴ - General Practitioner, Associate Professor of Primary Care and Clinical Director of the NIHR Community Healthcare MedTech and IVD Cooperative,
Dr Rebecca Cannings-John⁵ - Principal Research Fellow in Statistics.

¹ Division of Population Medicine and PRIME Centre Wales, Cardiff University
² Population Data Science, Swansea University Medical School, Faculty of Medicine, Health & Life Science, Swansea University
³ Division of Population Medicine, Cardiff University
⁴ Nuffield Department of Primary Care Health Sciences, Oxford University
⁵ Centre for Trials Research, Cardiff University

Corresponding Author

Leigh Sanyaolu
Division of Population Medicine,
Cardiff University,
3rd Floor,
Neuadd Meirionnydd,
Heath Park,
Cardiff, CF14 4YS UK
Email: [email protected]

🖋 How to cite this work

Prophylactic antibiotics to prevent recurrent UTIs and risk of antibiotic resistance: target trial emulation using the SAIL databank

To be added

📃 Funding

This research is funded by the Welsh Government through Health and Care Research Wales (NIHR-FS-2021-LS).

❤ Acknowledgements

This study makes use of anonymised data held in the Secure Anonymised Information Linkage (SAIL) Databank. We would like to acknowledge all the data providers who make anonymised data available for research.

🤝 Project approval

All research has been completed under the permission and approval of the SAIL independent Information Governance Review Panel (IGRP) project number 1161. Further details of this process can be found on the SAIL Databank website (https://saildatabank.com/)

♻️ License

Shield:

This work is licensed under a Creative Commons Attribution 4.0 International License.

This is the github repository to store SQL and R scripts and code lists used for the ImPART project lead by Leigh Sanyaolu. SAIL project number 1169