diff --git a/lib/modules/manager/pep621/extract.spec.ts b/lib/modules/manager/pep621/extract.spec.ts
index 37bd318ea6e550..049397b4f0c49a 100644
--- a/lib/modules/manager/pep621/extract.spec.ts
+++ b/lib/modules/manager/pep621/extract.spec.ts
@@ -605,5 +605,25 @@ describe('modules/manager/pep621/extract', () => {
         ],
       });
     });
+
+    it('should resolve dependencies with template', async () => {
+      const content = codeBlock`
+        [project]
+        name = "{{ name }}"
+        dynamic = ["version"]
+        requires-python = ">=3.7"
+        license = {text = "MIT"}
+        {# comment #}
+        dependencies = [
+          "blinker",
+          {% if foo %}
+          "packaging>=20.9,!=22.0",
+          {% endif %}
+        ]
+        readme = "README.md"
+      `;
+      const res = await extractPackageFile(content, 'pyproject.toml');
+      expect(res?.deps).toHaveLength(2);
+    });
   });
 });
diff --git a/lib/modules/manager/pep621/utils.ts b/lib/modules/manager/pep621/utils.ts
index faf88e2006cc29..9b6dde9bfbedd6 100644
--- a/lib/modules/manager/pep621/utils.ts
+++ b/lib/modules/manager/pep621/utils.ts
@@ -127,7 +127,7 @@ export function parsePyProject(
   content: string,
 ): PyProject | null {
   try {
-    const jsonMap = parseToml(content);
+    const jsonMap = parseToml(content, { removeTemplates: true });
     return PyProjectSchema.parse(jsonMap);
   } catch (err) {
     logger.debug(
diff --git a/lib/modules/manager/poetry/artifacts.ts b/lib/modules/manager/poetry/artifacts.ts
index d5582f619c5910..5888c7dbeee9a4 100644
--- a/lib/modules/manager/poetry/artifacts.ts
+++ b/lib/modules/manager/poetry/artifacts.ts
@@ -95,7 +95,7 @@ export function getPoetryRequirement(
 function getPoetrySources(content: string, fileName: string): PoetrySource[] {
   let pyprojectFile: PoetryFile;
   try {
-    pyprojectFile = parseToml(content) as PoetryFile;
+    pyprojectFile = parseToml(content, { removeTemplates: true }) as PoetryFile;
   } catch (err) {
     logger.debug({ err }, 'Error parsing pyproject.toml file');
     return [];
diff --git a/lib/modules/manager/poetry/extract.spec.ts b/lib/modules/manager/poetry/extract.spec.ts
index 5801cd73c93e6b..59b1f65fff531c 100644
--- a/lib/modules/manager/poetry/extract.spec.ts
+++ b/lib/modules/manager/poetry/extract.spec.ts
@@ -496,5 +496,23 @@ describe('modules/manager/poetry/extract', () => {
         ]);
       });
     });
+
+    it('parses package file with template', async () => {
+      const content = codeBlock`
+        [tool.poetry]
+        name = "{{ name }}"
+
+        {# comment #}
+        [tool.poetry.dependencies]
+        python = "^3.9"
+        {% if foo %}
+        dep1 = "^1.0.0"
+        {% endif %}
+      `;
+      const res = await extractPackageFile(content, filename);
+      expect(res?.deps).toHaveLength(2);
+      expect(res?.deps[0].depName).toBe('python');
+      expect(res?.deps[1].depName).toBe('dep1');
+    });
   });
 });
diff --git a/lib/util/schema-utils.ts b/lib/util/schema-utils.ts
index de637250c8f9cf..d4843358ddbd2f 100644
--- a/lib/util/schema-utils.ts
+++ b/lib/util/schema-utils.ts
@@ -258,7 +258,7 @@ export const MultidocYaml = z.string().transform((str, ctx): JsonArray => {
 
 export const Toml = z.string().transform((str, ctx) => {
   try {
-    return parseToml(str);
+    return parseToml(str, { removeTemplates: true });
   } catch {
     ctx.addIssue({ code: 'custom', message: 'Invalid TOML' });
     return z.NEVER;
diff --git a/lib/util/toml.spec.ts b/lib/util/toml.spec.ts
index b219c42b659158..514dd9ad02aa8c 100644
--- a/lib/util/toml.spec.ts
+++ b/lib/util/toml.spec.ts
@@ -28,4 +28,25 @@ describe('util/toml', () => {
 
     expect(() => parseToml(input)).toThrow(SyntaxError);
   });
+
+  it('should parse content with templates', () => {
+    const input = codeBlock`
+      [project]
+      name = "{{ value }}"
+
+      {# comment #}
+      [tool.poetry.dependencies]
+      {% if enabled %}
+      python = "^3.12"
+      {%+ endif -%}
+    `;
+    expect(parseToml(input, { removeTemplates: true })).toStrictEqual({
+      project: { name: '' },
+      tool: {
+        poetry: {
+          dependencies: { python: '^3.12' },
+        },
+      },
+    });
+  });
 });
diff --git a/lib/util/toml.ts b/lib/util/toml.ts
index 51814334a56de6..5cfa86ac064af7 100644
--- a/lib/util/toml.ts
+++ b/lib/util/toml.ts
@@ -1,6 +1,22 @@
 import { getStaticTOMLValue, parseTOML } from 'toml-eslint-parser';
+import { regEx } from './regex';
 
-export function parse(input: string): unknown {
-  const ast = parseTOML(input);
+export interface TomlOptions {
+  removeTemplates?: boolean;
+}
+
+export function parse(input: string, options?: TomlOptions): unknown {
+  const massagedContent = massageContent(input, options);
+  const ast = parseTOML(massagedContent);
   return getStaticTOMLValue(ast);
 }
+
+function massageContent(content: string, options?: TomlOptions): string {
+  if (options?.removeTemplates) {
+    return content
+      .replaceAll(regEx(/{%.+?%}/gs), '')
+      .replaceAll(regEx(/{{.+?}}/gs), '')
+      .replaceAll(regEx(/{#.+?#}/gs), '');
+  }
+  return content;
+}